Pentinmikko N., Iqbal S., Mana M., Andersson S., Cognetta A.B. 3rd, Suciu R.M., Roper J., Luopajärvi K., Markelin E., Gopalakrishnan S., Smolander O.P., Naranjo S., Saarinen T., Juuti A., Pietiläinen K., Auvinen P., Ristimäki A., Gupta N., Tammela T., Jacks T., Sabatini D.M., Cravatt B.F., Yilmaz Ö.H., Katajisto P. (2019) Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature 571(7765): 398-402. (PubMed Link) (PDF)


Kikani C.K., Wu X., Fogarty S., Kang S.A.W., Dephoure N., Gygi S.P., Sabatini D.M., Rutter J. (2019) Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. Proc Natl Acad Sci U S A epub ahead of print. (PubMed Link) (PDF)


Li Y., Muffat J., Omer Javed A., Keys H.R., Lungjangwa T., Bosch I., Khan M., Virgilio M.C., Gehrke L., Sabatini D.M., Jaenisch R. (2019) Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proc Natl Acad Sci U S A116(19): 9527-9532. (PubMed Link) (PDF)


Garcia-Bermudez J., Baudrier L., Bayraktar E.C., Shen Y., La K., Guarecuco R., Yucel B., Fiore D., Tavora B., Freinkman E., Chan S.H., Lewis C., Min W., Inghirami G., Sabatini D.M., Birsoy K. (2019) Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 567(7746): 118-122. (PubMed Link) (PDF)


Shen K., Valenstein M.L., Gu X., Sabatini D.M. (2019) Arg-78 of Nprl2 catalyzes GATOR1-stimualted GTP hydrolysis by the Rag GTPases. J Biol Chem. epub ahead of print. (PubMed Link) (PDF)


Bayraktar E.C., Baudrier L., Özerdem C., Lewis C.A., Chan S.H., Kunchok T., Abu-Remaileh M., Cangelosi A.L., Sabatini D.M., Birsoy K., Chen W.W. (2019) MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proc Natl Acad Sci U S A. 116(1):303-312. (PubMed Link) (PDF)


Adelmann C.H., Wang T., Sabatini D.M., Lander E.S. (2019) Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. Methods Mol Biol. 1907:125-136. (PubMed Link) (PDF)


Wedel J., Bruneau S., Liu K., Kong S.W., Sage P.T., Sabatini D.M., Laplante M., Briscoe D.M.(2019) DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation. Am J Transplant epub ahead of print. (PubMed Link) (PDF)


Heo J.M., Ordureau A., Swarup S., Paulo J.A., Shen K., Sabatini D.M., Harper J.W. (2018) RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Sci Adv. 4(11):eaav0443. (PubMed Link) (PDF)


Kory N., Wyant G.A., Prakash G., Uit de Bos J., Bottanelli F., Pacold M.E., Chan S.H., Lewis C.A., Wang T., Keys H.R., Guo Y.E., Sabatini D.M. (2018) SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science 362(6416): pii:eaat9528. (PubMed Link) (PDF)


Shen K., Sabatini D.M. (2018) Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proc Natl Acad Sci U S A 5115(38): 9545-9550. (PubMed Link) (PDF)


Kanarek N., Keys H.R., Cantor J.R., Lewis C.A., Chan S.H., Kunchok T., Abu-Remaileh M., Freinkman E., Schweitzer L.D., Sabatini D.M. (2018) Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559:632-636. (PubMed Link) (PDF)


Wyant G.A., Abu-Remaileh M., Frenkel E. M., Laqtom N. N., Dharamdasani V. Lewis C.A., Chan S. H., Heinze I., Ori A., Sabatini D.M. (2018) NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science 360(6390): 751-758. (PubMed Link) (PDF)


Yu Z., Surface L.E., Park C.Y., Horlbeck M.A., Wyant G.A., Abu-Remaileh M., Peterson T.R., Sabatini D.M., Weissman J.S., O'Shea E.K. (2018) Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife 7: pii: e36620. (PubMed Link) (PDF)


Mihaylova M.M., Cheng C.W., Cao A.Q., Tripathi S., Mana M.D., Bauer-Rowe K.E., Abu-Remaileh M., Clavain L., Erdemir A., Lewis C.A., Freinkman E., Dickey A.S., La Spada A.R., Huang Y., Bell G.W., Deshpande V., Carmeliet P., Katajisto P., Sabatini D.M., Yilmaz O.H. (2018) Fasting Activated Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell 22: 769-778. (PubMed Link) (PDF)


Rohde, J.M., Brimacombe, K.R., Liu, L., Pacold, M.E., Yasgar, A., Cheff, D.M., Lee, T.D., Rai, G., Baljinnyam, B., Li, Z., Simeonov, A., Hall, M.D., Shen, M., Sabatini, D.M., Boxer, M.B. (2018) Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry S0968-0896(18): 30042-30047. (PubMed Link) (PDF)


Shen, K., Huang, R.K., Brignole, E.J., Condon, K.J., Valenstein, M.L., Chantranupong, L., Bomaliyamu, A., Choe, A., Hong, C., Yu, Z., Sabatini, D.M. (2018) Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature 556:64-69. (PubMed Link) (PDF)


Yuskaitis, C.J., Jones, B.M., Wolfson, R.L., Super, C.E., Dhamne, S.C., Rotenberg, A., Sabatini, D.M., Sahin, M., Poduri, A. (2018) A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 111:99-101.  (PubMed Link) (PDF)


Minton, D.R., Nam, M., McLaughlin, D.J., Shin, J., Bayraktar E.C., Alvarez, S.W., Sviderskiy, V.O., Papagiannakopolous, T., Sabatini, D.M., Birsoy, K., Possemato, R. (2018) Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Molecular Cell 69(4): 610-621.e5. (PubMed Link) (PDF)


Reczek C.R., Birsoy K., Kong H., Martinez-Reyes I., Wang T., Gao P., Sabatini D.M., Chandel N.S. (2017) A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology 13(12): 1274-1279.(PubMed Link) (PDF)


Alvarez, S.W., Sviderskiy, V.O., Terzi, E.M., Papagiannakopoulos, T., Moreira,  A.L., Adams, S., Sabatini, D.M. Birsoy, K., Possemato, R. (2017) NFS1 undergoes positive selection in lung tumours and protects cells from       ferroptosis. Nature 551(7682): 639-643. (PubMed Link) (PDF)


Abu-Remaileh M., Wyant G.A., Kim C., Laqtom N.N., Abbasi M., Chan S.H. Freinkman E., Sabatini D.M. (2017) Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes. Science 358(6364): 807-813. (PubMed Link) (PDF)


Gu X., Orozco J.M., Saxton R.A., Condon, K.J., Liu G.Y., Krawczyk P.A., Scaria S.M., Harper J.W., Gygi S.P., Sabatini D.M. (2017) SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science 358(6364): 813-818. (PubMed Link) (PDF)


Sabatini D.M. (2017) Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences 114(45): 11818-11825. (PubMed Link) (PDF)


Wyant G.A., Abu-Remaileh M., Wolfson R.L., Chen W.W., Freinkman E., Danai L.V., Vander Heiden M.G., Sabatini D.M. (2017) mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell 171: 642-654. (PubMed Link) (PDF)


Shen K., Choe A., Sabatini D.M. (2017) Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell 68(3): 552-565.e8. (PubMed Link) (PDF)


Chen W.W., Freinkman E., Sabatini D.M. (2017) Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites. Nature Protocols 12 (10): 2029-2250. (PDF)


Wolfson R.L., Sabatini D.M. (2017) The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metabolism 26 (2): 301-309. (PubMed Link) (PDF)


Ersching J., Efeyan A., Mesin L., Jacobsen J.T., Pasqual G., Grabiner B.C., Dominguez-Sola D., Sabatini D.M., Victora G.D. (2017) Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity 46 (6): 1045-1058.e6 (PubMed Link) (PDF)


Caron A., Mouchiroud M., Gautier N., Labbé S.M., Villot R., Turcotte L., Secco B., Lamoureux G., Shum M., Gélinas Y., Marette A., Richard D., Sabatini D.M., Laplante M. (2017) Loss of hepatic DEPTOR alters the metabolic transition to fasting. Molecular Metabolism 6 (5): 447-458. (PubMed Link)(PDF)


Ilic N., Birsoy K., Aguirre A.J., Kory N., Pacold M.E., Singh S., Moody S.E., DeAngelo J.D., Spardy N.A., Freinkman E., Weir B.A., Tsherniak A., Cowley G.S., Root D.E., Asara J.M., Vazquez F., Widlund H.R., Sabatini D.M., Hahn W.C. (2017) PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. PNAS 114 (17): E3434-E3443. (PubMed Link)(PDF)


Cantor, J.R., Abu-Remaileh, M., Kanarek, N., Freinkman, E., Gao, X., Louissaint Jr., A., Lewis, C.A., Sabatini, D.M., (2017) Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell 169 (2): 258-272.e17 (PubMed Link) (PDF)


Kalaitzidis D., Lee D., Efeyan A., Kfoury Y., Nayyar N., Sykes D.B., Mercier F.E., Papazian A., Baryawno N., Victora G.D., Neuberg D., Sabatini D.M., Scadden D.T., (2017) Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. Journal of Clinical Investigation 127(4): 1405-1413 (Pubmed Link) (PDF)


Wolfson, R.L., Chantranupong, L., Wyant, G.A., Gu, X., Orozco, J.M., Shen, K., Condon, K.J., Petri, S., Kedir, J., Scaria, S.M., Abu-Remaileh, M., Frankel, W.N., Sabatini, D.M., (2017) KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature 543: 438-442. (PubMed Link) (PDF)


Saxton, R.A., Sabatini, D.M., (2017) mTOR Signaling in Growth, Metabolism, and Disease. Cell 168 (6): 960-976. (PubMed Link) (PDF)


Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD, (2017) A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genetics 49 (2): 193-203. (PubMed Link) (PDF)


Wang, T., Yu, H., Hughes, N.W., Liu, B., Kendirli, A., Klein, K., Chen, W.W., Lander, E.S., Sabatini, D.M., (2017) Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell 168 (5): 890-903. (PubMed Link) (PDF)


Saxton, R. A., K. E. Knockenhauer, T. U. Schwartz and D. M. Sabatini (2016). "The apo-structure of the leucine sensor Sestrin2 is still elusive." Sci Signal 9(446): ra92. (PubMed Link) (PDF)

Chen, W.W., Freinkman, E., Wang, T., Birsoy, K. Sabatini, D.M. (2016) Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell 6(5): 1324-1337. (PDF) (Supp. Table 1) (Supp. Table 2) (Supp. Table 3)

Saxton, R.A., Chantranupong, L., Knockenhauer, K.E., Schwartz, T.U., Sabatini, D.M. (2016) Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Nature 536(7615): 229-233. (PubMed Link) (PDF) (Supp. Data)

Chantranupong L., Sabatini, D.M. (2016) Cell biology: The TORC1 pathway to protein destruction. Nature 536(7615): 155-156. (PubMed Link) (PDF)

Strong, R., Miller, R.A., Antebi, A., Astle, C.M., Bogue, M., Denzel, M.S., Fernandez, E., Flurkey, K., Hamilton, K.L., Lamming, D.W., Javors, M.A., de Magalhães, J.P., Marinez, P.A., McCord, J.M., Miller, B.F., Müller, M., Nelson, J.F., Ndukum, J., Rainger, G.E., Richardson, A., Sabatini, D.M., Salmon, A.B., Simpkins, J.W., Steegenga, W.T., Nadon, N.L., Harrison, D.E. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell [Epub ahead of print](PubMed Link) (PDF)

Dominguez-Brauer, C., Hao, Z., Elia, A.J., Fortin, J.M., Nechanitzky, R., Brauer, P.M., Sheng, Y., Mana, M.D., Chio, I.I., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M.A., Wakeham, A., Yilmaz, O.H., Sabatini, D.M., van Es, J.H., Clevers, H., Sato, T., Mak, T.W, .Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell [Epub ahead of print](PubMed Link) (PDF) (Supp. Data)

Pacold, M.E., Brimacombe, K.R., Chan, S.H., Rohde, J.M., Lewis, C.A., Swier, L.J., Possemato, R., Chen, W.W., Sullivan, L.B., Fiske, B.P., Cho, S., Freinkman, E., Birsoy, K., Abu-Remaileh, M., Shaul, Y.D., Liu, C.M., Zhou, M., Koh, M.J., Chung, H., Davidson, S.M., Luengo, A., Wang, A.Q., Xu, X., Yasgar, A., Liu, L., Rai, G., Westover, K.D., Vander Heiden, M.G., Shen, M., Gray, N.S., Boxer, M.B., Sabatini, D.M. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chem Biol 12(6): 452-458.(PubMed Link) (PDF)

Chantranupong, L., Scaria, S.M., Saxton, R.A., Gygi, M.P. Shen, K., Wyant, G.A., Wang, T., Harper, J.W., Gygi, S.P., Sabatini, D.M. (2016) The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell 165(1): 153-164. (PubMed Link) (PDF and Supplemental Information)

*Beyaz, S., *Mana, M.D., *Roper, J., Kedrin, D. Saadatpour, A., Hong, S., Bauer-Rowe, K.E, Xifaras, M.E., Akkad A., Arias, E., Pinello, L., Katz, Y., Shinagare, S., Abu-Remaileh, M., Mihaylova, M.M, Lamming, D., Dogum, R., Guo, G., Bell, G.W., Selig, M., Nielsen, P., Gupta, N., Ferrone, C., Deshpande, V., Yuan, G., Orkin, S. Sabatini, D.M. & Yilmaz, O.H. (2016) High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 531: 53-58. (PubMed Link) (PDF) (Supp. Data) (Supp. Tabl

Wang, T., Lander, E.S., Sabatini, D.M., (2016) Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens. Cold Spring Harbor Protoc. 203-206.(PubMed Link) (PDF)

Wang, T., Lander, E.S., Sabatini, D.M., (2016) Viral Packaging and Cell Culture for CRISPR-Based Screens. Cold Spring Harbor Protoc. 289-296. (PubMed Link) (PDF)

Wang, T., Lander, E.S., Sabatini, D.M., (2016) Single Guide RNA Library Design and Construction. Cold Spring Harbor Protoc. 283-288. (PubMed Link) (PDF)

Caron, A., Labbé, S.M., Lanfray, D., Blanchard, P.G., Villot, R., Roy, C., Sabatini, D.M., Richard, D., Laplante, M. (2016) Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Molecular Metabolism 5(2): 102-112. (PubMed Link) (PDF)

Klionsky, D.J.,et al, (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222. (PubMed Link) (PDF)



Okosun, J., Wolfson, R.L., Wang, J., Araf, S., Wilkins, L., Castellano, B.M., Escudero-Ibarz, L., et al, Sabatini, D.M. & Fitzgibbon, J. (2015) Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics 8(2):183-188. (PubMed Link) (PDF) (Supp. Data)

Shaul, Y.D., Yuan, B., Thiru, P., Nutter-Upham, A., McCallum, S., Lanzkron, C., Bell, G.W., Sabatini, D.M. (2015) MERAV: a tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res. 44 (560-566)(PubMed Link) (PDF) (Supp. Data) (Supp. Table)

Saxton, R.A., Knockenhauer, K.E., Wolfson, R.L., Chantranupong, L., Pacold, M.E., Wang, T., Schwartz, T.U., Sabatini, D.M. (2015) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science 351(6268) 53-58. (PubMed Link) (PDF) (Supp. Data)

Wang, T., Birsoy, K., Hughes, N.W., Krupczak, K.M., Post, Y., Wei, J.J., Lander, E.S., Sabatini, D.M. (2015) Identification and characterization of essential genes in the human genome. Science 350(6264):1096-1101. (PubMed Link) (PDF) (Supp. Data)

Wolfson, R.L., Chantranupong, L., Saxton, R.A., Shen, K., Scaria, S.M., Cantor, J.R., Sabatini, D.M. (2015) Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351(6268) 43-48. (PubMed Link) (PDF) (Supp. Data)

Wheeler, D.B., Zoncu, R., Root, D.E., Sabatini, D.M., Sawyers, C.L. (2015) Identification of an oncogenic RAB protein. Science 350(6257):211-216. (PubMed Link) (PDF) (Supp. Data)

Schweitzer, L.D., Comb, W.C., Bar-Peled, L., Sabatini, D.M. (2015) Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTOR. Cell Reports 12(9) 1445-155. (PubMed Link) (PDF)

Birsoy, K., Wang, T., Chen, W.W., Freinkman, E., Abu-Remaileh, M., Sabatini, D.M. (2015) An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell 162(3):540-551. (PubMed Link) (PDF) (Supp. Data) (Supp. Data2)(Supp. Table)

Kim, D., Fiske, B.P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R.L., Chudnovsky, Y., Pacold, ME, Chen W.W., Cantor, J.R., Shelton, L.M., Gui, D.Y., Kwon, M., Ramkissoon, S.H., Ligon, K.L., Kang, S.W., Snuderl, M., Vander Heiden, M.G., Sabatini, D.M. (2015) SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520: 363-367. (PubMed Link) (PDF)

Katajisto, P., Döhla, J., Chaffer, C.L., Pentinmikko, N., Marjanovic, N., Iqbal, S., Zoncu, R., Chen, W., Weinberg, R.A., Sabatini, D.M. (2015) Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science 348:340-343. (PubMed Link) (PDF) (Supp. Data)

Chantranupong, L., Wolfson, R., Sabatini, D.M. (2015) Nutrient-Sensing Mechanisms across Evolution. Cell 161: 67-83. (PubMed Link) (PDF)

Strohecker, A.M., Joshi, S., Possemato, R., Abraham, R.T., Sabatini, D.M., White, E. (2015) Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene 34(45) 5662-5776. (PubMed Link) (PDF) (Supp. Data)

Efeyan, A., Comb, W.C., Sabatini, D.M. (2015) Nutrient-sensing mechanisms and pathways.Nature 517: 302-310. (PubMed Link) (PDF)

Wang, S., Tsun, Z., Wolfson, R.L., Shen, K., Wyant, G.A., Plovanich, M.E., Yuan, E.D., Jones, T.D., Chantranupong, L., Comb, W., Wang, T., Bar-Peled, L., Zoncu, R., Straub, C., Kim, C., Park, J., Sabatini, B.L., Sabatini, D.M. (2015) Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 347(6218): 188-194. (PubMed Link) (PDF) (Supp. Data)



Martz, C.A., Ottina, K.A., Singleton, K.R., Jasper, J.S., Wardell, S.E., Peraza-Penton, A., Anderson, G.R., Winter, P.S., Wang, T., Alley, H.M., Kwong, L.N., Cooper, Z.A., Tetzlaff, M., Chen, P.L., Rathmell, J.C., Flaherty, K.T., Wargo, J.A., McDonnell, D.P., Sabatini, D.M., Wood, K.C. (2014) Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 7(357): ra121. (PubMed Link) (PDF) (Supp. Data)(Supp. Table 1) (Supp. Table 2) (Supp. Table 3) (Supp. Table 4) (Supp. Table 5) (Supp. Table 6)

Wagle, N., Grabiner, B.C., Van Allen, E.M., Amin-Mansour, A., Taylor-Weiner, A., Rosenberg, M., Gray, N., Barletta, J.A., Guo, Y., Swanson, S.J., Ruan, D.T., Hanna, G.J., Haddad, R.I., Getz, G., Kwiatkowski, D.J., Carter, S.L., Sabatini, D.M., Jänne, P.A., Garraway, L.A., Lorch, J.H. (2014). Response and acquired resistance to everolimus in anaplastic thyroid cancer. New England Journal of Medicine 371(15): 1426-1433. (PubMed Link) (PDF)

Chantranupong, L., Wolfson, R.L., Orozco, J.M., Saxton, R.A., Scaria, S.M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S.P., Sabatini, D.M. (2014). The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1. Cell Reports 9: 1-8. (PDF with Supp. Data)

Shaul, Y.D., Freinkman, E., Comb, W.C., Cantor, J.R., Tam, W.L., Thiru, P., Kim, D., Kanarek, N., Pacold, M.E., Chen, W.W., Bierie, B., Possemato, R., Reinhardt, F., Weinberg, R.A. Yaffe, M.B., Sabatini, D.M. (2014). Dihydropyrimidine Accumulation Is Required for the Epithelial- Mesenchymal Transition. Cell 158:1094–1109. (PubMed Link) (PDF)

Lamming D.W., Mihaylova, M.M., Katajisto, P., Baar, E.L., Yilmaz, O.H., Hutchins, A., Gultekin, Y., Gaither, R., Sabatini, D.M. (2014). Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 13(5): 911-917. (PubMed Link) (PDF)

Lee, C.C., Freinkman, E., Sabatini, D.M., Ploegh, H.L. (2014). The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-Rich Repeat-Containing Protein 8D. J Biol Chem. 289(24) 17124-17131. (PubMed Link) (PDF)

Efeyan, A., Schweitzer, L.D., Bilate, A.M., Chang, S., Kirak, O., Lamming, D.W., Sabatini, D.M. (2014). RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice. Dev Cell. 29(3):321-329. (PubMed Link) (PDF) (Supp. Data)

Festuccia, W.T., Pouliot, P., Bakan, I., Sabatini, D.M., Laplante, M. (2014). Myeloid-specific rictor deletion induces m1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One 9(4):e95432. (PubMed Link) (PDF)

Bar-Peled, L., Sabatini, D.M. (2014). Regulation of mTORC1 by amino acids. Trends Cell Biol. pii: S0962-8924(14)00036-00041. (PubMed Link) (PDF)

Chen, W.W., Birsoy, K., Mihaylova, Snitkin, H., Stasinski, I., Yucel, B., Bayraktar, E.C., Carette, J.E., Clish, C.B., Brummelkamp, T.R., Sabatini, D. and Sabatini, D.M. (2014) Inhibition of ATPIF1 Ameliorates
Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells. Cell Rep. pii: S2211-1247(14)00162-00164. (PubMed Link) (PDF)

Birsoy, K., Possemato, R., Lobeer, F., Bayraktar, E., Thiru, P., Yucle, B., Wang, T., Chen, W., Clish, C., Sabatini, D.M., (2014) Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature 508(7494):108-112. (PubMed Link) (PDF) (Supp. Data 1) (Supp. Data 2)(Supp. Data 3)(Supp. Data 4)

Grabiner, B.C., Nardi, V., Birsoy, K., Possemato, R., Shen, K., Sinha, S., Jordan, A., Beck, A.H., Sabatini, D.M. (2014) A diverse array of cancer-associated mTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discover. 4: 554-563. (PubMed Link)(PDF) (Supp. Data)

Wagle, N., Grabiner, B.C., Van Allen, E.M., Hodis, E., Jacobus, S., Supko, J.G., Stewart, M., Choueiri, T.K., Gandhi, L., Cleary, J.M., Elfiky, A.A., Taplin, M.E., Stack, E.C., Signoretti, S., Loda, M., Shapiro, G.I., Sabatini, D.M., Lander, E.S., Gabriel, S.B., Kantoff, P.W., Garraway, L.A., Rosenberg, J.E. (2014) Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib. Cancer Discover. 4: 546-553. (PubMed Link)(PDF) (Supp. Data)

Mihaylova, M.M., Sabatini, D.M., Yilmaz, O.H., (2014) Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer. Cell Stem Cell. 14(3):292-305. (PubMed Link)(PDF)

Soliman, M.A., Abdel Rahman, A.M., Lamming, D.A., Birsoy, K., Pawling, J., Frigolet, M.E., Lu, H., Fantus, I.G., Pasculescu, A., Zheng, Y., Sabatini, D.M., Dennis, J.W., Pawson, T. (2014) The Adaptor Protein o66Shc Inhibits mTOR-Dependent Anabolic Metabolism. Sci. Signal 7(313):ra17. (PubMed Link)(PDF) (Supp. Data)

Chudnovsky, Y., Kim, D., Zheng, S., Whyte, W.A., Bansal, M., Bray, M.A., Gopal, S., Theisen, M.A., Bilodeau, S., Thiru, P., Muffat, J., Yilmaz, O.H., Mitalipova, M., Woolard, K., Lee, J., Nishimura, R., Sakata, N., Fine, H.A3, Carpenter, A.E., Silver, S.J., Verhaak, R.G., Califano, A., Young, R.A., Ligon, K.L., Mellinghoff, I.K., Root, D.E., Sabatini, D.M., Hahn, W.C., Chheda, M.G.(2014) ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep. 6(2):313-24. (PubMed Link)(PDF) (Supp. Data)

Wang, T., Wei, J.J., Sabatini, D.M., Lander, E.S. (2014) Genetic Screens in Human Cells Using the CRISPR/Cas9 System. Science 34(6166): 80-4. (PubMed Link)(PDF) (Supp. Data)


Byles, V., Covarrubias, A.J., Ben-Sahra, I., Lamming, D.W., Sabatini, D.M., Manning, B.D., Horng, T. (2013) The TSC-mTOR pathway regulates macrophage polarization. Nat Commun. 4:2834. (PubMed Link)(PDF) (Supp. Data)

Reiling, J.H., Olive, A.J., Sanyal, S., Carette, J.E., Brummelkamp, T.R., Ploegh, H.L., Starnbach, M.N., Sabatini, D.M. (2013) A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nat Cell Biol. 15: 1473-1485 (PubMed Link) (PDF) (Supp. Data)

Tsun, Z., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., Sabatini, D.M. (2013) The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1. Molecular Cell 52: 1-11(PubMed Link) (PDF) (Supp. Data)

Lamming, D.W., Demirkan, G., , Boylan, J.M., Mihaylova, M.M., Peng, T., Ferreira, J., Neretti, N., Salomon, A., Sabatini, D.M., and Gruppuso, P.A. (2013) Hepatic signaling by the mechanistic target of rapamycin complex2 (mTORC2). FASEB J. 28(1):300-315. (PubMed Link) (PDF) (Supp. Data)

Lamming, D.W., Sabatini, D.M. (2013) A Central Role for mTOR in Lipid Homeostasis. Cell Metab pii: S1550-4131(13)00326-4. (PubMed Link) (PDF)

Ye, L., Widlund, A.L., Sims, C.A., Lamming, D.W., Guan, Y., Davis, J.G., Sabatini, D.M., Harrison, D.E., Vang, O., Baur, J.A. (2013) Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging 5(7):539-550. (PubMed Link) (PDF)

Kang, S.A., Pacold, M.E., Cervantes, C.L., Lim, D., Lou, H.J., Ottina, K., Gray, N.S., Turk, B.E., Yaffe, M.B., Sabatini, D.M. (2013) mTORC1 Phosphorylation Sites Encode Their Sensititivity to Starvation and Rapamycin. Science 341(6144): 364-374. (PubMed Link) (PDF) (Supp. Data)

Efeyan, A., Sabatini, D.M., (2013) Nutrients and growth factors in mTORC1 activation. Biochem. Soc. Trans. 41: 902-905. (PubMed Link) (PDF)

Floyd, S.R., Pacold, M.E., Huang, Q., Clarke, S.M., Lam, F.C., Cannell, I.G., Bryson, B.D., Rameseder, J., Lee, M.J., Blake, E.J., Fydrych, A., Ho, R., Greenberger, B.A., Chen, G.C., Maffa, A., Del Rosario, A.M., Root, D.E., Carpenter, A.E., Hahn, W.C., Sabatini, D.M., Chen, C.C., White, F.M., Bradner, J.E., Yaffe, M.B. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498 (7453): 246-250. (PubMed Link) (PDF) (Supp. Data)

Sabatini, D.M., 2013, An interview with David Sabatini. Trends in Pharmacological Sciences 34(7): 359-360. (PDF)

Bar-Peled, L., Chantranupong, L., Cherniack, A.D., Chen, W.W., Ottina, K.A., Grabiner, B.C, Spear, E.D., Carter, S.L., Meyerson, M., Sabatini, D.M., (2013) A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1. Science 340(6136): 1100-1106. (PubMed Link) (PDF) (Supp. Data)

Curry, N.L., Mino-Kenudson, M., Oliver, T.G., Yilmaz, O.H., Yilmaz, V.O., Moon, J.Y., Jacks, T., Sabatini, D.M., Kalaany, N.Y. (2013) PTEN-null Tumors Cohabiting the Same Lung Display Differential Akt Activation and Sensitivity to Dietary Restriction. Cancer Discov. 3(8):908-921. (PubMed Link) (PDF)

Lamming, D.W., Ye, L., Astle, M.C., Baur, J.A., Sabatini, D.M., Harrison, D.E., (2013) Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 12(4): 712-718. (PubMed Link) (PDF)

Laplante, M., Sabatini, D.M., (2013) Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci. 126 (Pt 8): 1713-1719. (PubMed Link) (PDF)

Mercken, E.M., Crosby, S.D., Lamming, D.W., Jebailey, L., Krzysik-Walker. S., Villareal, D., Capri, M., Franceschi, C., Zhang, Y., Becker, K., Sabatini, D.M., de Cabo, R., Fontana L. (2013).Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 12(4): 645-651. (PubMed Link) (PDF)

Lamming, D.L., Ye, L., Sabatini, D.M., Baur, J.A. (2013) Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest. 23(3):980-989. (PubMed Link) (PDF)

Liu, Q., Xu, C., Kirubakaran, S., Zhang, X., Hur, W., Liu, Y., Kwiatkowski, N.P., Wang, J., Westover, K.D., Gao, P., Ercan, D., Niepel, M., Thoree, C.C., Kang, S.A., Patricelli, M.P., Wang, Y., Tupper, T., Altabef, A., Kawamura, H., Held, K.D., Chou,D.M., Elledge, S.J., Janne, P.A., Wong, K.K., Sabatini, D.M., Gray, N.S. (2013) Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR. Cancer Res. 73(8):2574-2586. (PubMed Link) (PDF) (Supp. Figure Legend and Tables 2-3) (Supp. Table 1) (Supp. Figures 1-4)

Efeyan, A., Zoncu, R., Chang, S., Gumper, I., Snitkin, H., Wolfson, R.L., Kirak, O., Sabatini, D.D., Sabatini, D.M. (2012) Regulation of the mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 493(7434):679-83. (PubMed Link) (PDF) (Supp. Data)


Bar-Peled, L., Sabatini, D.M. (2012) SnapShot: mTORC1 signaling a the lysosomal surface. Cell 151(6) 1390-1390e1. (PubMed Link) (PDF)

Birsoy, K., Wang, T., Possemato, R., Yilmaz, O.H., Koch, C.E., Chen, W., Hutchins, A., Gultekin, Y., Peterson, T.R., Carette, J.E., Brummelkamp, T.J., Clish, C. B., Sabatini, D.M. (2012) MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics 45(1):104-108. (PubMed Link) (PDF) (Supp. Data)

Cantor, J.R., Sabatini, D.M. (2012) Cancer Cell Metabolism: One Hallmark, Many Faces. Cancer Discovery 2(10):1-18. (PubMed Link) (PDF)

Bar-Peled, L., Schweitzer, L.D., Zoncu, R., Sabatini, D.M. (2012) Ragulator is a GEF for the RAG GTPases that signal amino acid levels to mTORC1. Cell 150: 1196-1208. (PubMed Link) (PDF) (Supp. Data)

Klionsky, D.J., et al. (2012) Guidelines for the use and interpretation of assays for monitoring authophay. Autophagy 8(4):445-544. (PubMed Link)

Ye, L., Varamini, B., Lamming, D. W., Sabatini, D.M., Laur, J.A., (2012) Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. Frontiers in Genetics in Aging 3(177):1-10. (PubMed Link) (PDF)

Lamming, D. W., Sabatini, D.M., Laur, J.A., (2012) Pharmacologic Means of Extending Lifespan. J Clin Exp Pathol S4: 002. (PDF)

Laplante, M., Horvat, S., Festuccia, W.T., Birsoy, K., Prevorsek, Z., Efeyan, A., Sabatini, D.M., (2012) Deptor Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metab 16:202-212. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1) (Supp. Table 2)

Birsoy, K., Sabatini, D.M., Possemato, R., (2012) Targeting cancer metabolism: a bedside lesson. Nature Medicine 18:1022-1023. (PubMed Link) (PDF)

Efeyan, A., Zoncu, R., Sabatini, D.M., (2012) Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med 18(9):524-33. (PubMed Link) (PDF)

Yilmaz, O., Kattajisto, P., Lamming. D.W., Gultekin, Y., Bauer-Rowe, K., Sengupta, S., Birsoy, K., Durson, A., Yilmaz, O., Selig, G., Nielsen, P., Mino-Kenudson, M., Zukerberg, L., Bhan, A.K., Deshapnde, V., Sabatini, D.M., (2012) mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486:490-495. (PubMed Link) (PDF) (Supp. Data) (Supp. Table)

Wood, K.C., Konieczkowski, D.J., Johannessen, C.M., Boehm, J.S., Tamayo, P., Botvinnik, O.B., Mesirov, J.P., Hahn, W.C., Root, D.E., Garraway, L.A., Sabatini, D.M., (2012) MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma. Sci. Signal 5(224):rs4. (PubMed Link) (PDF) (Supp. Data) (Supp. Table S4)

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D.W., Mizunuma, M., Narasihan, S.D., Neumann-Haefelin, Sabatini, D.M., Blackweel, K., (2012) Tor Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15:713-724. (PubMed Link) (PDF) (Supp. Data)

Thoreen, C., Chantranupong, L., Keys, H.R., Wang, T., Gray, N.S., Sabatini, D.M., (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485:109-113. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1) (Supp. Table 2) (Supp. Table 3)

Laplante, M., Sabatini, D.M., (2012) mTOR Signaling in Growth Control and Disease. Cell 149:274-293. (PubMed Link) (PDF)

Liu, Q., Ren, T., Fresques, T., Oppliger, W., Niles, B.J., Hur, W., Sabatini, D.M., Hall, M.N., Powers, T., Gray, N.S., (2012) Selective ATP-competitive inhibitors of TOR suppress rapamycin insensitive function of TORC2 in S. cerevisae. ACS Chem Biol. 7(6):982-987. (PubMed Link)(PDF) (Supp. Data)

Lamming, D.W, Ye, L., Katajisto, P., Concalves, M.D., Saitoh, M., Stevens, D.M., Davis, J.G., Salmon, A.B., Richardson, A., Ahima, R.S., Guertin, D.A., Sabatini, D.M., Baur, J.A., (2012) Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity. Science 335:1638-1643. (PubMed Link) (PDF) (Supp. Data)

Settembre, C., Zoncu, R., Medina, D.L., Vetrinil, F., Erdin, S., Erdin, S.U., Huynh, T., Ferron, M., Karsenty, G., Vellard, M.C., Facchinetti, V., Sabaitni, D.M., Ballabio, A., (2012) A lysosome-to-nucleus signaling mechanism senses and regulates the lysome via mTOR and TFEB. The EMBO Journal 31:1095-1108. (PubMed Link) (PDF)

Liu, Q., Kirubakara, S., Wooyoung, H., Niepel, M., Westover, K., Thoreen, C.C., Wang, J., Nil, J., Patrice, M.P., Vogel, K., Riddle, S., Waller, D.L., Traynor, R., Sanda, T., Zeng, Z., Kang, S.A., Zhao, J., Look, T., Sorger, P.K., Sabatini, D.M., Gray, N.S., (2011) Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target of rapamycin) inhibitors and characterization of their binding kinectics. J. Biol Chem 287:9742-9752. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1)


Laplante, M., Sabatini, D.M., (2011) mTOR Signaling.Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a011593 (PubMed Link) (PDF)

Liu, Q., Kang, S.A., Thoreen, C.C., Hur, W., Wang, J., Chang, J.W., Markhard, A., Zhang, J., Sim, T., Sabatini, D.M., Gray, N.S., (2011) Development of ATP-Competitive mTOR Inhibitors. Methods Mol Biol 821:447-460. (PubMed Link) (PDF)

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., Sabatini, D.M., (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H?-ATPase. Science 334:678-683. (PubMed Link) (PDF) (Supp. Data)

Wan, M., Leavens, K.F., Saleh, D., Easton, R.M., Guertin, D.A., Peterson, T.R., Kaestner, K.H., Sabatini, D.M., Birnbaum, M.J., (2011)Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism 14:516-527. (PubMed Link) (PDF) (Supp. Data)

Peterson, T.R., Sengupta, S.S., Harris, T.E., Carmack, A.E., Kang, S.A., Balderas, E., Guertin, D.A., Madden, K.L., Carpenter, A.E., Finck, B.N., Sabatini, D.M., (2011) mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell 146:408-420. (PubMed Link) (PDF) (Supp. Data)

Possemato, R., Marks, K.M., Shaul, Y.D., Pacold, M.E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.K., Jang, H.G., Jha, A.K., Chen, W.W., Barrett, F.G., Stransky, N., Tsun, Z.Y., Cowley, G.S., Barrentina., J., Kalaany, N.Y., Hsu, P.P., Ottina, K., Chan, A.M., Yuan, B., Garraway, L.A., Root, D.E., Mino-Kenudson, M., Brachtel, E.F., Driggers, E.M., Sabatini, D.M., (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476:346-350. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1) (Supp. Table 2) (Supp. Table 3)

Reiling, J., Clish, C., Carette, J., Varadarajan, M., Brummelkamp, T., Sabatini, D.M., (2011) A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediiator in the response to tunicamycin. PNAS 108:11756-11765. (PubMed Link) (PDF) (Supp. Data)

Hsu, P. P., Kang, S. A., Rameseder, J., Zhang, Y., Ottina, K., Lim, D., Peterson, T. R., Yongmun, C., Gray, N. S., Yaffe, M. B., Marto, J. A., Sabatini, D.M., (2011) The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling. Science 332:1317-1322. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1) (Supp. Table 2) (Supp. Table 3) (Supp. Table 4)

Lamming, D., Sabatini, D.M., (2011) A Radical Role for TOR in Longevity.Cell Metabolism 332:923-925. (PubMed Link) (PDF)

Liu, Q., Wang, J., Kang, S.A., Thorreen, C. C., Hur, W., Choi, H.G., Waller, D.L., Sim, T., (2011) Discovery and optimization of potnent and slective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability. Bioorg Med Chem Lett 21:4036-4040. (PubMed Link) (PDF)

Zoncu, R., Sabatini, D.M., (2011) Cell biology. The TASCC of Secretion. Science 332:923-925. (PubMed Link) (PDF)

Sheen, J.H., Zoncu, R., Kim, D., Sabatini, D.M., (2011) Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Cancer Cell 19(5):613-628. (PubMed Link) (PDF) (Supp. Data)

Liu, Q., Wang, J., Kang, S.A., Thoreen, C.C., Hur, W., Ahmed, T., Sabatini, D.M., Gray, N.S. (2011) Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphtyhridin-2(1H)-one(Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer. J Med Chem 54:1473-1480. (PubMed Link) (PDF)

(Supp. Data)

Lindquist, R.A., Ottina, K.A., Wheeler, D.B., Hsu, P.P., Thoreen C.C., Guertin, D.A., Ali, S.M., Shaul, Y.D., Lamprecht, M.R., Madden, K.L., Papallo, A.R., Jones, T.R., Sabatini, D.M., Carpenter, A.E. (2011) Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Res 21:433-446. (PubMed Link) (PDF) (Supp. Data) (Supp. Table 1) (Supp. Table 2) (Supp. Pipeline Zip file)


Sengupta S., Peterson, T.R., Laplante M., Oh S., Sabatini D.M. (2010) mTORC1 controls fasting-induced ketogenesis and its modulating by ageing. Nature 468:1100-1104. (PubMed Link) (PDF) (Supp. Data)

Zoncu R., Efeyan A., Sabatini D.M. (2010) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 12:21-35. (PubMed Link) (PDF) (Supp. Data)

Sengupta S., Peterson T.R., Sabatini D.M. (2010) Regulation of the mTOR Complex I Pathway by Nutrients, Growth Factors, and Stress. Molecular Cell 40(2):310-322. (PubMed Link) (PDF)

Liu Q., Chang J.W., Wang J., Kang S.A., Thoreen C.C., Markhard A., Hur W., Zhang J., Sim T., Sabatini D.M., Gray N.S. (2010) Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3(trifluoromethyl)phenl)-99(quinolin-3-yl)benzo[h][16] naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer. J Med Chem 53:7146-7155. (PubMed Link) (PDF) (Supp. Data)

Liu Q., Thoreen C.C., Wang J., Sabatini D.M., Gray N.S. (2010) mTOR Mediated Anti-Cancer Drug Discovery. Drug Discover Today Ther Strategy 6(2):47-55. (PubMed Link) (PDF)

Fonslow B.R., Kang S.A., Gestaut D.R., Graczyk B., Davis T.N., Sabatini D.M., Yates Iii JR. (2010) Native Capillary Isoelectric Focusing for the Separation of Protein Complex Isoforms and Subcomplexes. Anal Chem 82:6643-6651. (PubMed Link) (PDF)

Yip, C.K., Murata, K., Walz, T., Sabatini, D.M., Kang, S.A. (2010) Structure of the human mTOR complex I and its implications for rapamycin inhibition. Molecular Cell 38:768-774. (PubMed Link) (PDF) (Supp. Data)

Dekelver, R.C. et al (2010) Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res 20:1133-1142. (PubMed Link) (PDF) (Supp. Data) (Supp. Movie Link)

Boulbes, D. et al (2010) Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Research 8: 896-906. (PubMed Link) (PDF) (Supp. Data)

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A.L., Nada, S. and Sabatini, D.M. (2010) Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids. Cell 141:290-303. (PubMed Link) (PDF of paper and supplement)


Laplante, M. and Sabatini, D.M. (2009) An emerging role of mTOR in lipid biosynthesis. Current Biology 19:R1046-52. (PubMed Link) (PDF)

Efeyan, A. and Sabatini, D.M. (2009) mTOR and cancer: many loops in one pathway. Curr Opinion in Cell Biology 22:169-176. (PubMed Link) (PDF)

Barbie, D.A. et al, (2009) Systemic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462:108-112. (PubMed Link) (PDF)

Laplante, M. and Sabatini, D.M. (2009) mTOR signaling at a glance. J. Cell Science 122:3589-94. (PubMed Link) (PDF)

Wood, K.C. and Sabatini, D.M. (2009) Growth signaling at the nexus of stem cell life and death. Cell Stem Cell 5:232-234. (PubMed Link) (PDF)

Peterson, T.R., Laplante, M., Thoreen, C.C., Sancak, Y., Kang, S.A., Kuel WM, Gray, N.S., and Sabatini, D.M. (2009) DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell 137:873-886. (PubMed Link) (PDF) (Supp. Data) (Table S1)

Thoreen, C.C. and Sabatini, D.M. (2009) Rapamycin inhibits mTORC1, but not completely. Autophagy 5: Epub. (PubMed Link) (PDF)

Guertin, D.A. and Sabatini, D.M. (2009) The pharmacology of mTOR inhibition. Science Signaling 2: pe24. (PubMed Link) (PDF)

Kalaany, N.Y. and Sabatini, D.M. (2009) Tumours with PI3K activation are resistant to dietary restriction. Nature 458:725-731. (PubMed Link) (PDF) (Supp. Data)

Jones, T.R., Carpenter, A.E., Lamprecht, M.R., Moffat, J., Silver, S.J., Grenier, J.K., Castoreno, A.B., Eggert, U.S., Root, D.E., Golland, P. and Sabatini, D.M. (2009) Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci. USA 106:1826-1831. (PubMed Link) (Link to Epub) (PDF) (Supp. Data)

Guertin, D.A., Stevens, D.M., Saitoh, M., Kinkel, S., Crosby, K., Sheen, J.-H., Mullholland, D.J., Magnuson, M.A., Wu, H., and Sabatini, D.M. (2009) mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice. Cancer Cell 15:148-159. (PubMed Link) (PDF) (Supp. Data)

Thoreen, C.C., Kang, S.A., Chang, J.W., Liu, Q, Zhang, J., Gao, Y., Reichling, L.J., Sim, T. Sabatini, D.M., and Gray, N.S. (2009) An ATP-competitive mTOR inhibitor reveals rapamycin-insensitive functions of mTORC1. J Biol Chem 284:8023-8032. (PubMed Link) (PDF) (Supp. Data)


Luo, B., Cheung, H.W., Subramanian, A., Sharifnia, T., Okamoto, M., Yang, X., Hinkle, G., Boehm, J.S., Beroukhim, R., Weir, B.A., Mermel, C., Barbie, D.A., Awad, T., Zhou, X., Nguyen, T., Piqani, B., Li, C., Golub, T.R., Meyerson, M., Hacohen, N., Hahn, W.C., Lander, E.S., Sabatini, D.M., Root, D.E. (2008) Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci USA 105:20380-203805. (PubMed Link) (PDF) (Supp. Data)

Jones, T.R., Kang, I.H., Wheeler, D.B., Lindquist, R.A., Papallo, A., Sabatini, D.M., Golland, P., and Carpenter, A.E. (2008) CellProfiler Analyst: data exploration and analysis software for complex image-based screens. BMC Bioinformatics 9:482. (PubMed Link) (PDF)

Hsu, P.P. and Sabatini, D.M. (2008) Cancer Cell Metabolism: Warburg and Beyond. Cell 134:703-707. (PubMed Link) (PDF)

Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L., and Sabatini, D.M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501. (PubMed Link) (PDF) (Supp. Data)

Reiling, J.H. and Sabatini, D.M. (2008) Increased mTORC1 Signaling UPRegulates Stress. Molecular Cell 29:533-535. (PubMed Link) (PDF)


Guertin, D.A. and Sabatini, D.M. (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9-22. (PubMed Link) (PDF)

Sancak, Y., Thoreen, C.C., Peterson, T.R., Lindquist, R.A., Kang, S.A., Spooner, E., Carr, S.A., and Sabatini, D.M. (2007) PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase. Molecular Cell 25:903-915. (PubMed Link) (PDF) (Supp. Data)

Moffat, J., Reling, J.H., Sabatini, D.M. (2007) Off-target effects associated with long dsRNAs in Drosophila RNAi screens. Trends Pharmacol Sci. (PubMed Link) (PDF)

Lamprecht, M.R., Sabatini, D.M., Carpenter, A.E. (2007) CellProfiler: free, versatile software for automated biological image analysis. Biotechniques 42:71-75. (PubMed Link) (PDF)


Zeng, Z., Sarbassov, D.D., Samudio, I.J., Yee, K.W., Munsell, M.F., Jackson, C.E., Giles, F.J., Sabatini, D.M., Andreeff, M., Konopleva, M. (2006) Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood (PubMed Link) (PDF)

Guertin, D.A., Stevens, D.M., Thoreen, C.C., Burds, A.A., Kalaany, N.Y., Moffat, J., Brown, M., Fitzgerald, K.J., Sabatini, D.M. (2006) Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1. Developmental Cell 11:859-871. (PubMed Link) (PDF) (Supp. Data)

Carpenter, A.E., Jones, T.R., Lamprecht, M.R., Clarke, C., Kang, I.H., Friman, O., Guertin, D.A., Chang, J.H., Lindquist, R.A., Moffat, J., Golland, P., Sabatini, D.M. (2006) CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biology 7:R100. (PubMed Link) (PDF)

Reiling, J.H. and Sabatini, D.M. (2006) Stress and mTORture signaling. Oncogene 25: 6373-6383. (PubMed Link) (PDF)

Echeverri, C.J., Beachy, P.A., Baum, B., Boutros, M., Buchholz, F., Chanda, S.K., Downward, J.,Ellenberg, J., Fraser, A.G., Hacohen, N., Hahn, W.C., Jackson, A.L., Kiger, A., Linsley, P.S., Lum, L., Ma, Y., Mathey-Prevot, B., Root, D.E., Sabatini, D.M., Taipale, J., Perrimon, N., Bernards, R. (2006) Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods 3:777-779. (PubMed Link) (PDF)

Root, D.E., Hacohen, N., Hahn, W.C., Lander, E.S., Sabatini, D.M. (2006) Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods 3:715-719. (PubMed Link) (PDF)

Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr S.A., and Sabatini D.M. (2006) mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Current Biology 16:1865-1870. (PubMed Link) (PDF) (Supp. Data)

Sabatini D.M. (2006) mTOR and cancer: insights into a complex relationship. Nature Reviews Cancer 6:729-734. (PubMed Link) (PDF)

Guertin, D.A., Guntur K.V., Bell, G.W., Thoreen, C.C. and Sabatini, D.M.(2006) Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division. Current Biology 16:958-970. (PubMed Link) (PDF) (Supp. Data)

Sarbassov, D.D., Ali, S,M, Sengupta, S., Sheen, J.-H., Hsu, P.P., Bagley, A.F., Markhard, A.L. and Sabatini, D,M. (2006) Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB. Molecular Cell 22:159-168. (PubMed Link) (PDF) (Supp. Data)

Moffat, J., Grueneberg, D.A., Yang, X., Kim, S.Y., Kloepfer, A.M., Hinkle, G., Piqani, B., Eisenhaure, T.M., Luo, B., Grenier, J.K., Carpenter, A.E., Foo, S.Y., Stewart, S.A., Stockwell, B.R., Hacohen, N., Hahn, W.C., Lander, E.S., Sabatini, D.M., and Root, D.E. (2006) A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen. Cell 124:1283-1298. (PubMed Link) (PDF) (Supp. Data)

Guertin, D.A and Sabatini, D.M. (2006) Cell Size Control. In: Encylopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester [doi:10.1038/npg.els.0003359] (PDF)

Moffat, J. and Sabatini, D.M. (2006) Building mammalian signalling pathways with RNAi screens. Nature Reviews Molecular Cell Biology 7:177-187. (PubMed Link) (PDF)

Bailey, S.N., Ali, S,M, Carpenter, A.E., Higgins, C.O., Sabatini, D,M.(2006) Microarrays of lentiviruses for gene function screens in immortalized and primary cells. Nature Methods, 3:117-122. (PubMed Link) (PDF)


Sarbassov, D.D., Ali, S,M, Sabatini, D,M. (2005) Growing roles for the mTOR pathway. Current Opinion in Cell Biology 17:596-603. (PubMed Link) (PDF)

Sarbassov, D.D. and Sabatini, D.M. (2005) Redox regulation of the nutrient-sensitive Raptor-mTOR pathway complex. J Biol Chem 280:39505-39509. (PubMed Link) (PDF)

Guertin, D.A and Sabatini, D.M. (2005) An expanding role for mTOR in cancer. Trends in Molecular Medicine 37:S25-S30. (PubMed Link) (PDF)

Wheeler, D.B, Carpenter, A.E., and Sabatini, D.M. (2005) Cell microarrays and RNA interference chip away at gene function. Nature Genetics Supplement 37:S25-S30. (PubMed Link) (PDF)

Ali, S.M. and Sabatini, D.M. (2005) Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 280:19445-8. (PubMed Link) (PDF)

Sarbassov, D.D., Guertin, D.A., Ali, S.M., and Sabatini, D.M. (2005) Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR complex. Science 307:1098-1101. (PubMed Link) (PDF) (Supp. Data)


Bailey S.N., Sabatini D.M., Stockwell B.R. (2004) Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens. Proc Natl Acad Sci USA 101:16144-16149. (PubMed Link) (PDF)

Wheeler, D.B., Bailey, S.N., Guertin, D.A., Carpenter, A.E., Higgins, C.O., Sabatini, D.M. (2004) RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Nature Methods 1:127-132. (PubMed Link) (PDF) (PDF of News&Views article referring to this work) (Drosophila RNAi cell microarray home page)

Sarbassov, D., Ali, S.M., Kim, D.-H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current Biology 14:1296-1302. (PubMed Link) (PDF) (Supp. Data)

Guertin, D. A., Kim, D.-H., and Sabatini, D. M. (2004) “Growth Control Through the mTOR Network” in Cell Growth: Control of Cell Size (Edited by Michael N. Hall, Martin Raff, and George Thomas). 193-234. Cold Spring Harbor Laboratory Press.

Thoreen, C.C. and Sabatini, D.M. (2004) Huntingtin aggregates ask to be eaten. Nature Genetics 36: 553-554. (PubMed Link) (PDF)

Carpenter, A.E. and Sabatini, D.M. (2004) Systematic Genome-Wide Screens of Gene Function. Nature Reviews Genetics 5:11-22. (PubMed Link) (PDF)


Schalm, S.S., Fingar, D.C., Sabatini, D.M., and Blenis J. (2003) TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function. Current Biology 13:797-806. (PubMed Link) (PDF)

Kim, D.-H., Sarbassov, D., Ali, S.M., Latek, R.R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D.M. (2003) GbL: a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between mTOR and raptor. Molecular Cell 11:895-904. (PubMed Link) (PDF) (siRNAs used)

Stewart, S.A., Dykxhoorn, D.M., Palliser, D., Mizuno, H., Yu, E.Y., An, D.S., Sabatini, D.M., Chen, I.S.Y., Hahn, W.C., Sharp, P.A., Weinberg, R.A., and Novina, C.D. (2003) Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9:493-501. (PubMed Link) (PDF)


Kim, D.-H., and Sabatini, D.M. (2002) Raptor and mTOR: subunits of a nutrient-sensitive complex. Current Topics in Microbiology and Immunology 279:259-270. (PubMed Link)

Wu, R., Bailey, S. and Sabatini, D.M. (2002) Cell biological applications of transfected cell microarrays. Trends in Cell Biology 12:485-488. (PubMed Link) (PDF)

Kim, D.-H., Sarbassov, D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D.M. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery. Cell 110:163-175. (PubMed Link) (PDF) (Supp. Data) (siRNAs used)

Bailey, S., Wu, R. and Sabatini, D.M. (2002) Applications of transfected cell microarrays to drug discovery. Drug Discovery Today, High-throughput Technologies Supplement: S113-118. (PubMed Link) (PDF)

Peng, T., Golub, T., and Sabatini, D.M. (2002) The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid or glucose deprivation. Mol Cell Bio 22: 5575-5584. (PubMed Link) (PDF) (Rapachip website)

Hahn, W.C., Dessain, S.K., Brooks, M.W., King, J.E., Elenbass, B., Sabatini, D.M., DeCaprio, J.A., and Weinberg, R.A. (2002) Enumeration of the pathways required for tumorigenic transformation of human cells. Mol Cell Bio 22: 2111-2123. (PubMed Link) (PDF)


Hentges, K.E., Sirry, B., Gingras, A.C., Sarbassov, D., Sonenberg, N., Sabatini, D.M., Peterson, A.S. (2001). FRAP/mTOR is required for proliferation and patterning during embryonic development in mouse. Proc Natl Acad Sci USA 98:13796-13801. (PubMed Link) (PDF)

Ziauddin, J. and Sabatini, D.M. (2001) Microarrays of cells expressing defined cDNAs. Nature 411:107-110. (PubMed Link) (PDF) (Reverse Transfection Homepage)

Kumar, V., Sabatini, D., Pandey, P., Gingras, A.C., Majumder, P.K., Kumar, M., Yuan, Z.M., Carmichael, G., Weichselbaum, R., Sonenberg, N., Kufe, D., Kharbandam S. (2000) Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J Biol Chem 275:10779-10787. (PubMed Link) (PDF)

Kumar, V, Pandey, P, Sabatini, D.M., Kumar, M, Majumder, P.K., Bharti, A., Carmichael, G., Kufe, D., Kharbanda, S. (2000) Functional interaction between RAFT1/FRAP/mTOR and protein kinase c d in the regulation of cap-dependent initiation of translation. EMBO 19:1087-1097. (PubMed Link) (PDF)

Sabatini, D.M., Barrow, R.K., Blackshaw, S., Burnett, P.E., Lai, M.L., Field, M.E., Bahr,B.A., Kirsch, J., Betz, H., Snyder, S.H. (1999) Interaction of RAFT1 with the Clustering Protein Gephyrin Required for Rapamycin-Sensitive Signaling. Science 284:1161-1164. (PubMed Link) (PDF)

Walensky, L.D., Dawson, T.M., Steiner, J.P., Sabatini, D.M., Suarez, J.D., Klinefelter, G.R., Snyder, S.H. (1998) The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Mol Med 4:502-514. (PubMed Link) (PDF)

Burnett, P.E., Blackshaw, S., Mai, M.L., Qureshi, I.A., Burnett, A.F., Sabatini, D.M. and Snyder, S.H. (1998) Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton.Proc Natl Acad Sci USA 95:8351-8356. (PubMed Link) (PDF)

Snyder, S.H., Sabatini, D.M., Lai, M.M., Steiner, J.P., Hamilton, G.S. and Suzdak, P.D. (1998) Neural actions of immunophilin ligands. Trends Pharm Sci. 19:21-26. (PubMed Link) (PDF)

Burnett, P.E., Barrow, R.K., Cohen, N.A., Snyder, S.H. and Sabatini, D.M. (1998) RAFT1 phosphorylation of translational regulators p70 S6 kinase and 4E-BP1.Proc Natl Acad Sci USA 95:1432-1437. (PubMed Link) (PDF)

Sabatini, D.M., Lai, M.M. and Snyder S.H. (1997) Neural roles of the immunophilins. Molecular Neurobiology 15:223-239. (PubMed Link) (PDF)

Khan, A.A., Soloski, M.J., Sharp, A.H., Schilling, G., Sabatini, D.M., Li, S.H., Ross, C.A., and Snyder, S.H. (1996). Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Triphosphate Receptor. Science 273:503-507. (PubMed Link) (PDF)

Sabatini, D.M., Pierchala, B.A., Barrow, R.K., Schell, M.J., and Snyder, S.H. (1995). The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity. J Biol Chem 270:20875-20878. (PubMed Link) (PDF)

Snyder, S.H. and Sabatini, D.M. (1995). Immunophilins and the nervous system. Nature Medicine 1:32-37. (PubMed Link) (PDF)

Cameron, A.M., Steiner, J.P., Sabatini, D.M., Kaplin, A.I., Walensky, L.D. and Snyder, S.H. (1995). Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium influx. Proc. Natl Acad Sci USA 92:1784-1788. (PubMed Link) (PDF)

Erdjument-Bromage, H., Lui, M., Sabatini D.M., Snyder S.H. and Tempst, P. (1994). High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Science 3: 2435-2446. (PubMed Link) (PDF)

Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P. and Snyder S.H. (1994). RAFT1: A Mammalian Protein That Binds to FKBP12 in a Rapamycin-Dependent Fashion and is Homologous to Yeast TORs. Cell 78:35-43. (PubMed Link) (PDF)

Baccarini, M., Sabatini, D.M., App, H., Rapp, U.R. and Stanley, E.R. (1990). Colony Stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO 9:3649-3657. (PubMed Link) (PDF)